Standards and Reagents

Frequent calibration for greater confidence in your results Eliminate manual preparation of custom standard calibration mixes with ACQUITY Advanced Polymer Chromatography (APC) Calibration Standards, which provide the right number of data points for your targeted molecular weight (MW) range. ACQUITY APC Calibration Standards are specifically designed to match the molecular weight range of the ACQUITY APC Columns. ACQUITY APC polymethylmethacrylate and polystyrene standards are configured into Low, Middle, and High Molecular Weight Calibration Kits, as well as a convenient Method Development Kit that includes the full separation range of all three kits combined. These chromatography standards are designed to provide a maximum range of narrow standard data points for a specific column set or molar mass range. With ACQUITY APC Calibration Standards, you can conduct calibration with 3-5x shorter cycle times, enabling you to run more replicates and more easily include calibration with each test set. With increased calibration frequency, you can have higher confidence in the accuracy of each test run. View more products

Accurate amino acid composition analysis for HPLC, UHPLC, and UPLC Accurately separating, identifying, and quantitating amino acids is challenging. The amino acid sequence is the primary structure of a protein and it is unique to a particular peptide or protein. Amino acids are also key ingredients in the cell culture media and feed used to prepare recombinant proteins. Determining amino acid composition in protein/peptide hydrolysates, foods, feeds, and pharmaceutical preparations is important, as regularly monitoring individual amino acid consumption can help you optimize the conditions in the bioreactor. You can easily analyze amino acids with the many manual and automated solutions that use pre-column derivatization from Waters. With Waters AccQ•Tag Ultra UPLC/UHPLC reagent kit and AccQ•Fluor HPLC reagent kit, you’ll have what your lab needs for accurate amino acid composition analysis. AccQ•Tag Ultra and AccQ•Fluor derivatization solutions utilize a single reagent to tag both primary and secondary amino acids, reducing reagent usage by 50% compared to competitive kits that require two separate derivatization compounds. This streamlined approach simplifies the gradient and eliminates the need to switch detection wavelengths mid-method. View more products

Increase safety, quality, and efficiency for environmental analysis Waters instrumentation, standards, and sample preparation products are used for environmental analysis in laboratories throughout the world. Application analyses for Waters UPLC, UPC², UPLC-MS/MS, UPLC/QTof MS, and GC-MS/MS systems include pesticides, trace metals, cations and anions. Help ensure safety and compliance Increase laboratory efficiency Improve quality of results View more products

Solutions that seamlessly integrate with your QC systems From QC testing of final product, to meeting the demand for new products with additional nutritional value, food manufacturers face difficult challenges. Waters can help meet those challenges with standards and reagents that offer the sensitivity, reproducibility, and versatility required to ensure you can profitably manage laboratory requirements, we have made a unique commitment to the food industry, and we are ready to partner with you to improve and optimize your analytical capabilities. Test complex food and beverage samples consistently and routinely Improve confidence in results and instrumentation Take advantage of Waters’ unique commitment and experience in the food industry View more products

Maximize data quality with high-purity modifiers and buffers Improving analyte retentivity and peak shape in liquid chromatography (LC) is critical, and mobile-phase additives (i.e., strong acids or buffers) are a common way to do just that. MS applications specifically require high purity mobile-phase additives to reduce background contribution and ensure data quality. IonHance modifiers can be used for LC and LC-MS techniques, such as reversed-phase separations of proteins, peptides, oligonucleotides, and small molecules. Purified to achieve low metal content and high-quality standards, IonHance modifiers can improve the sensitivity, retentivity, and peak shape of even the toughest separations. View more products

High purity formulations and reagents for RNA/DNA assays Analytical approaches for testing and characterizing gene-based therapies are always evolving. As larger and more complex nucleic acids are subjected to chromatographic analysis, it becomes increasingly important to have quick access to high quality reference materials for method qualification and system suitability. Waters now offers the ability to choose the reference material that most closely matches your molecule. Our analytical standards are comprised of individual and pre-mixed oligonucleotide and nucleic acid material that provide coverage for a wide range of molecular weights and chemistries. These standards can help you quickly evaluate method suitability, column health, detector sensitivity and site proficiency for SEC, IPRP, HILIC, and AEX analyses. Manufacturing quality standards and reagents is in our DNA. View more products

Benchmark and validate your peptide columns with ease Verify your column performance upon receipt and monitor column condition over column lifetime to save valuable research and development time with Waters Peptide Standards. Run your peptide separations on any UPLC, HPLC, or LC-MS system with ease and confidence using these specifically formulated, prepackaged standards. Prepackaged in Waters vials, Peptide Standards eliminate the need to prepare complex mixtures – providing ease of use while minimizing sample loss and discrepancies. Waters Peptide, Phosphopeptide, and Protein Digest Standards were designed to complement Waters Peptide Columns and system solutions to help evaluate, validate, and benchmark system performance. Waters manufacturing and quality control testing procedures ensure each standard is batch tested with the same functional specification test and column on relevant systems, so you’ll achieve consistent batch-to-batch and column-to-column performance regardless of application demands. View more products

Benchmark and validate your protein columns with ease Save valuable research and development time with Waters Protein Standards. Run your protein analysis with ease and confidence with these specifically formulated, prepackaged standards. Prepackaged in Waters vials, Protein Standards allow for direct solubilization - providing ease of use while minimizing sample loss and discrepancies. Waters Protein Standards and Protein Mixes were designed to complement Waters Protein Columns and system solutions to help evaluate, validate, and benchmark system performance. Waters manufacturing and quality control testing procedures ensure each standard is batch tested with the same functional specification test and column on relevant systems, so you’ll achieve consistent batch-to-batch and column-to-column performance regardless of application demands. View more products

Benchmarking for repeat performance, higher uptime, and faster troubleshooting Reduce repeat runs from questionable data by evaluating and benchmarking your HPLC, UHPLC, UPLC, or LC-MS chromatography system before analyzing critical analytes with Waters Quality Control (QC) Reference Materials. With consistent use , Waters QC Reference Materials will help you achieve confidence in your results, reduce troubleshooting and re-run time, and compare cross-lab results. The Waters QC Reference Material portfolio is a unique collection of specifically formulated standards and mixtures that are ready to use. Regardless of your lab type, Waters recommends benchmarking a new chromatographic system prior to usage with a QC Reference Material to ensure the system is in good working order. To ensure confidence in your results, run and save your initial results, then continue comparing the QC Reference Material results to the previous benchmark before running critical assays or changing any hardware, columns, or mobile phases. View more products

Enhance the quality of in-solution enzymatic protein digestions Labs around the globe are trying to simplify digestion protocols and improve throughput of analysis. Waters patented RapiGest SF Surfactant was designed with your lab’s efficiency in mind, significantly decreasing proteolytic digestion time, and enabling same-day digestions with mass spectrometry (MS) compatibility. RapiGest SF radically enhances the speed and percent recovery of protein enzymatic digestions. This patented anionic surfactant accelerates the in-solution production of peptides generated by proteases, such as Trypsin, Asp-N, Glu-C, Lys-C, and PNGase F. Many hydrophobic proteins are resistant to proteolysis because their cleavage sites are inaccessible to endoproteases. RapiGest SF facilitates the digestion of proteolytically resistant proteins and increases the solubility of hydrophobic proteins and peptides. RapiGest SF is an MS-compatible mild protein denaturant that helps solubilize and unfold proteins, making them more amenable to cleavage without denaturing or inhibiting common proteolytic enzymes like conventional denaturants. This enables use of lesser amounts of expensive endoproteases. View more products

Support accurate small molecule analysis with easy testing, validation, and troubleshooting Ultra-Performance Liquid Chromatography (UPLC) combined with mass spectrometric (MS) detection is used successfully in the analysis of small molecules. The Waters Small Molecule Standards consumable line provides relevant application-specific standards for evaluating and running many small molecule applications, including MetID, omics, bioanalysis, and extractables and leachables. View more products

Accurately establish and document system performance Waters System Performance and Application Standards help ensure that your UPLC, HPLC, GC, GC-MS, and LC-MS and SFC systems can produce valid results day in and day out. Thousands of laboratories trust Waters to help them establish and document the performance of their instruments. We offer a broad range of products for most calibration needs, all backed by the Waters reputation and professional support team. View more products